Monokines regulate glycosylation of acute-phase proteins.

Monokines regulate glycosylation of acute-phase proteins

The acute-phase response to inflammatory stimuli, characterized by increased synthesis of acute-phase proteins (APP), is often accompanied by changes in the glycosylation patterns of some of these proteins. While expression of APP genes in hepatocytes is regulated by monokines, mechanisms governing changes in glycosylation are not known. Exposure of human hepatoma cell line Hep 3B to conditione...

acute phase proteins efficacy in differential diagnosis

introduction: evaluating patient with acute scrotum is based on medical history (e.g. age), physical examination, blood tests, urine analysis and imaging studies. differential diagnosis may be difficult. efficacy of serum acute phase proteins in patients with acute scrotum was assessed in this study. materials and methods : 45 patients were recruited and allocated within three sub-groups; acute...

Serum IgA, acute phase proteins, and glycosylation of alpha 1-acid glycoprotein in ankylosing spondylitis.

Several investigators have suggested that gastrointestinal inflammation has a role in the pathogenesis of ankylosing spondylitis. To test this hypothesis markers of gastrointestinal immunostimulation, as manifested by serum IgA concentrations, were compared with serum markers of inflammation, as manifested by acute phase proteins. Serum samples from 45 unrelated Caucasian patients with ankylosi...

Acute Phase Proteins – Regulation

Acute-phase Proteins

The discovery of large amounts of C-reactive protein (CRP) in the serum of patients during the acute phase of pneumococcal pneumonia in 1930 focused interest on the plasma protein changes that accompany inflammatory states. CRP and other plasma proteins whose concentrations rose significantly under such circumstances were accordingly referred to as acute-phase proteins (APP). The subsequent rea...